PERKIN ELMER NexION 1000 ICP Mass Spectrometer

Alat Laboratorium Mikrobiologi

Deskripsi produk
NexION 1000 ICP Mass Spectrometer

The NexION® 1000 ICP-MS is the ideal high-throughput system for routine, multi-elemental, trace-level analyses that meet regulatory standards – and that works within your budget. It features a host of proprietary technologies that combine to deliver exceptional speed and operational simplicity, making your lab more efficient than ever before.

Part Number N8150048

Overview

Ideal for high-throughput testing laboratories running routine multi-element analysis, the NexION 1000 ICP-MS features:

A dedicated SMARTintro™ sample introduction module with integrated All Matrix Solution delivers long-term stability while handling high dissolved solids
Three quadrupoles and the unique capability of the Universal Cell to switch between Collision and Reaction modes using a single gas combine to offer efficient interference removal, requiring minimal switching times (<15 sec) and increasing your productivity
Extended Dynamic Range capabilities offer the ability to detect high- and low-level elements in a single sample run
The industry’s fastest data acquisition speed (100,000 points/sec) to handle any particle size
A new solid-state RF generator with revolutionary LumiCoil™ technology – first ICP-MS RF coil that requires no maintenance or cooling
Triple Cone Interface with Quadrupole Ion Deflector, delivering no maintenance beyond the cones
Syngistix™ software provides an intuitive interface that mirrors your workflow, with left-to-right, icon-based navigation that guides you through your analysis. Plus, it’s a cross-platform solution, easing the transition from technique to technique
The NexION 1000 ICP-MS – No interference between you and better throughput.


Specifications
21 CFR Part 11 Compatible
Yes
Depth
69.0 cm
Height
75.0 cm
Model Name
NexION 1000
Portable
No
Product Brand Name
NexION
Warranty
1 Year
Weight
150.0 kg
Width
81.0 cm
Application Brief
Arsenic Speciation Analysis in Rice Following Method GB 5009.11-2014 to Ensure Safety

Rice represents a dietary staple for over half of the world's population. However, in recent years, concerns have been raised over the presence of high levels of arsenic (As), where this carcinogenic metalloid can be accumulated at levels far exceeding ambient concentrations. Since China is the world's largest producer of rice, the Chinese government released a national standard method in 2014 for food safety – GB 5009.11– to aid the evaluation of As species in rice and rice products. In this document, HPLC-ICP-MS is identified as the preferred analytical technique.

In this study, five arsenic species were characterized in a commercial rice sample and certified reference material using a gradient anion-exchange method in accordance with GB 5009.11. The analysis was performed using a PerkinElmer NexSAR™ HPLC-ICP-MS speciation solution, consisting of a NexSAR inert HPLC coupled to a NexION® ICP-MS.


PDF 1 MB
PM10 and PM2.5 Air Pollution Monitoring and Source Apportionment in Asia Using the NexION ICP-MS

Concern about air pollution has been growing rapidly, with most of the focus on gaseous pollutants. Airborne particulates, especially small ones, are rapidly gaining attention due to their impact on human health, as smaller particles can be carried over long distances by wind and penetrate deep into the lungs, where contaminants can have direct interaction with lung tissue and the associated blood vessels. Airborne particulates are classified as PM10 for those with aerodynamic diameters less than 10 µm and PM2.5 for those with aerodynamic diameters less than 2.5 µm.

PM2.5 regulations have been implemented throughout the world, and in order to implement a regime to reduce the concentration of PM2.5, it is important to determine the origins of these particulates, hence the need to collect and analyze them.

ICP-MS is often the analytical instrument of choice for such applications due to its low detection limits and wide linear dynamic range. This work describes the collection, sample preparation and inorganic elemental analysis of atmospheric PM10 and PM2.5 using PerkinElmer’s NexION® ICP-MS.


PDF 1 MB
Application Note
A Single Cell-ICP-MS Method to Study the Treatment Efficiency of Algaecide for Toxic Algal Bloom Control

Toxic cyanobacterial blooms were reported worldwide in various aquatic systems, including freshwater rivers, lakes, reservoirs, and eutrophied coastal marine habitats. Cyanobacterial blooms might be caused by a combination of multiple factors, including eutrophication, solar radiation, temperature, current patterns and other associated factors. Their proliferation in aquatic environments can cause death or toxin accumulation in aquatic animals and then, indirectly or directly, affect human health. Microcystis aeruginosa (M. aeruginosa) bloom is the most common harmful algal bloom (HAB) and is widely studied in various fields.

Copper sulfate is an algaecide frequently used for controlling algae growth. The mechanism of copper (Cu)-based algaecide for algal bloom control is not well understood. The amount of Cu required to kill an individual algae cell and the morphology of the cell after being killed is still unknown. Quantification measurement of these phenomena is even more difficult due to the lack of appropriate methodology.

This work demonstrates that single cell (SC)-ICP-MS provides an effective method for the determination of copper algaecide at the cellular level, leveraging the NexION® ICP-MS with Syngistix™ Single Cell Application software module.


PDF 2 MB
Advantages of a High Throughput Sample Introduction System in the Analysis of Drinking Waters Using ICP-MS (Method 200.8)

This application note presents a high throughput method evaluating 27 analytes in drinking water following U.S. EPA 200.8 with a 3-5 fold reduction in sample analysis time through the use of the HTS high throughput sample introduction system fully integrated with the NexION® ICP-MS and Syngistix™ for ICP-MS software.


PDF 1 MB
Analysis of Cerium Dioxide Nanoparticles in Soil Using Single Particle ICP-MSThis work demonstrates a robust method using SP-ICP-MS technology to detect CeO2 NPs which were extracted from soil samples with tetrasodium pyrophosphate (TSPP). Over the past few decades, engineered nanoparticles (ENPs) have been increasingly used in many commercial products. As a result, more and more ENPs have been released into the environment, which raises concerns over their fate, toxicity and transport therein.
PDF 1 MB
Analysis of Drinking Water using Universal Collision-Reaction Gas Technology on the NexION 1000 ICP-MS

The most significant challenge in trace element analysis of drinking water is ensuring detection capability that complies with the regulatory framework at the same time as maximizing sample throughput. The NexION® 1000 ICP-MS solves the challenges that high-throughout laboratories face using a robust, simple method and a single gas mixture. This application note explains how the NexION 1000 exceeds expectations on detection capability and details the benefits of using the single gas mixture for a wide range of elements, even those where the first ionization energy is relatively high (e.g. selenium).


PDF 1 MB
Assessing the Fate of Nanoparticles During Coagulation Using SP-ICP-MS
PDF 2 MB
Boron Isotope Ratio Analysis Using the NexION ICP-MS

Boron (B) is studied for its isotope ratio composition in a range of paleoproxy, geochemical, nuclear, medical, and archeological applications. ICP-MS is recognized as a powerful technique for boron isotope analysis. Quadrupole ICP-MS is versatile and not exclusively dedicated to isotope ratio measurements, therefore the appreciation of its isotope ratio capabilities can bring high-quality isotopic ratio analysis into the reach of laboratories with varied analysis needs.

This application note describes the analysis of boron isotope ratios using a NexION® ICP-MS, demonstrating the instrument’s capabilities to measure at the best possible level of precision.


PDF 3 MB
Characterization of TiO2 Nanoparticle Release from Fabrics By Single Particle ICP-MS

In the textile industry, the use of titanium dioxide (TiO2) nanoparticles (NPs) is increasing due to their ability to provide UV protection, increase the hydrophilic nature of fabrics, provide antibacterial characteristics, and reduce odors. This work demonstrates the ability of PerkinElmer's NexION® Single Particle ICP-MS with Syngistix™ Nano Application Software Module to both detect and measure TiO2 nanoparticles released from textiles.


PDF 516 KB
Determination of Methyl and Inorganic Mercury in Fish with the NexSAR HPLC-ICP-MS Speciation Solution

Consumption of seafood is the primary exposure route of methylmercury for humans, emphasizing the importance of accurately measuring methylmercury in fish. As with all analytical method setup, the determination of methylmercury content in fish has to meet the criteria of modern analytical methodology, including reproducibility, repeatability, and accuracy at low concentrations. These characteristics are facilitated by using an HPLC system with a metal-free flow path, which eliminates the possibility of mercury leaching into the mobile phase, thereby affecting the lowest concentrations which can be measured.

This work demonstrates the accurate and reliable determination of methyl- and inorganic mercury in fish using PerkinElmer’s NexSAR™ HPLC-ICP-MS speciation solution, leveraging the inert, metal-free flow path of the NexSAR HPLC system in combination with the robust and versatile NexION® ICP-MS.


PDF 1 MB
Determination of Trace Elements in Eye Drops with the NexION ICP-MS

Eye drops are commonly used medications which are available both over-the-counter and as prescriptions in various forms. Because eye drops are classified as a parenteral medication and have relatively large daily doses, the inorganic components in eye drops must be present at low concentrations. As a result, ICP-MS is the most appropriate technique for the determination of trace elements in eye drops.

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. This work discusses the sample preparation and analysis of Class 1, 2, and 3 elements in a variety of eye drops with the NexION ICP-MS, following the criteria defined in ICH Q3D. The developed methodology (both sample preparation and analytical) demonstrates both accuracy and stability.


PDF 475 KB
Digestion, Testing, and Validation of Heavy Metals in Cannabis

Owing to the toxicity of heavy metals, it is increasingly important to test cannabis flowers and other cannabis derivatives so that patient and consumer safety is maintained as the use of cannabis becomes more common. This need has translated into an increasing demand for testing cannabis flowers and other cannabis derivatives for toxins such as the heavy metals cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg). In this application note, we present data to illustrate the successful validation of the Titan MPS™ Microwave Sample Preparation System and the NexION® ICP-MS for the determination of heavy metals in cannabis flower according to the validation protocols set in USP General Chapter <233>, which are commonly used for evaluation of the levels of elemental impurities in samples.


PDF 1 MB
Extraction of Gold Nanoparticles from Fish Larvae and Soils

Gold nanoparticles (AuNPs) are widely used in industrial and medical applications. They are known to form naturally during the weathering of Au-bearing mineral deposits, as well as the transformation of gold nuggets and particles. In freshwater systems, they bioaccumulate in aquatic organisms, as shown on test fish species such as zebrafish and guppy.

Several techniques are available to determine gold concentrations in samples – however, few methods have been developed to characterize the size fractions of nanoparticulate gold in complex organic materials. This work is a feasibility study to measure AuNPs in complex organic matrices using Single Particle ICP-MS, as may be applied to environmental monitoring or exploration, demonstrating the ability of PerkinElmer’s NexION® ICP-MS Single Particle Analyzer to reliably detect and characterize nanoparticles in soil and aquatic samples.


PDF 1 MB
Monitoring the Fate of Silver Nanoparticles in Seawater Using Single Particle ICP-MS

Single Particle (SP) ICP-MS is an analytical technique that has demonstrated tremendous potential for the measurement and characterization of metal-containing nanoparticles (NPs) in a wide range of sample types, including environmental. One of the most challenging matrices is seawater due to its high salt content, which causes severe difficulties when analyzed for NPs due to matrix suppression and cone clogging.

This work demonstrates the ability of the NexION® ICP-MS, coupled to the dedicated Syngistix™ Nano Application software module, to measure silver (Ag) nanoparticles in seawater and track their transformations over time.


PDF 1 MB
Multi-Element Analysis of Drinking Water Using the NexION 1000 ICP-MS Following ISO 17294-2 and (EU) 2020/2184

The analysis of elemental content is critical to ensuring the quality and safety of drinking water. In this regard, the international standard method ISO 17294 outlines the analysis of elements in water samples using ICP-MS, providing the general guidelines for using the ICP-MS technique as well as the determination of selected elements. Directive (EU) 2020/2184 aims to protect human health from the adverse effects of any contamination of water intended for human consumption by ensuring that it is wholesome and clean.

ICP-MS technology is ideal as it offers multi-element detection capability, low detection limits, high-speed of analysis, wide dynamic range, etc. However, it is affected by plasma as well as matrix-based polyatomic interferences and doubly charged species, which need to be accounted for by applying mathematical corrections and/or collision/reaction mechanisms.

This work demonstrates the ability of the NexION® 1000 ICP-MS with Universal Cell technology, which can be operated in both Collision and Reaction modes to tackle polyatomic interferences, to meet and/or exceed the specifications contained within the ISO and EU directives for the analysis of drinking water.


PDF 1 MB
Multi-Elemental Analysis of Soils Using the NexION ICP-MS

The elemental analysis of soils is of vital importance not only for agriculture, but also from an environmental perspective. Toxic metals enter soil primarily through pollution and can be taken up directly by humans in various manners, potentially causing acute or chronically toxic responses. Therefore, the identification of pollutants and determination of the level of toxic elements present in the soil are important aspects to be considered.

This work demonstrates the ability of the NexION® ICP-MS to easily analyze 21 elements in soil over an extended period of time with outstanding accuracy and stability, delivering a complete solution to addressing the challenges in soil analysis.


PDF 1 MB
Quantification of Low Levels of Hexavalent Chromium in Water Using a NexSAR HPLC-ICP-MS

Due to rising concerns over the carcinogenic properties of hexavalent chromium (Cr6+) in drinking water, many national and regional water standards are looking to lower the maximum allowable levels of total chromium and hexavalent chromium in potable waters. And in order to assess trace concentrations of Cr6+ in drinking water, it is necessary to have an instrument capable of measuring parts per trillion (ppt) concentrations of Cr and possessing a wide linear dynamic range – HPLC-ICP-MS is often the instrumentation of choice in such applications.

This work demonstrates an ion exchange method for the characterization of Cr6+ in potable drinking water using our NexSAR HPLC-ICP-MS Speciation Solution. Discover the advantages of the inert and metal-free fluid path of the NexSAR Inert HPLC coupled with the NexION® ICP-MS’ Universal Cell Technology™ for these types of analyses – download this application note.


PDF 1 MB
Quantification of Nanoparticle Uptake into Cancer Cells using Single Cell ICP-MSNanoparticles (NPs) have been of significant interest over the last two decades as they offer attractive benefits for drug delivery to overcome limitations in conventional chemotherapy. Nanoparticles can be engineered to carry both drugs and imaging probes to simultaneously detect and treat cancer. They may also be designed to specifically target diseased tissues and cells in the body. A number of nanoparticlebased cancer therapeutics have been approved for clinical use and/or are currently under development.
PDF 939 KB
Rapid Measurement of Nanoparticles in Seawater Using Single Particle ICP-MS with All Matrix Solution
PDF 1 MB
Speciation of Hexavalent Chromium in Children's Toys According to EN 71-3 Category II with the NexSAR HPLC-ICP-MS

Testing for harmful metal(loid)s that may be included in raw materials, processes, paints and additives used in the manufacturing processes of children's toys has been mandated by the regulation EN 71-3. This regulation recommends specific testing methods and maximum allowable concentrations of leachable metals and metalloids such as Al, As, B, Ba, Cd, Co, Cr (III), Cr (VI), Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, organotin, Sr and Zn in parts of toys, with the exclusion of general packaging materials.

This work shows a method for the measurement of hexavalent chromium in different toy material categories in accordance with method EN 71-3 Category II, leveraging the unique combination and capabilities of the NexSAR™ Inert HPLC coupled to the robust NexION® ICP-MS.


PDF 918 KB
Transport of Nanoparticles from Coated Surfaces through Physical ContactThis work investigated the transfer of Ag and CuO nanoparticles from consumer products via simulated dermal contact by using textile wipes as a surrogate using PerkinElmer’s NexION® ICP-MS single particle analyzer with the unique Syngistix™ Nano Application software module for data collection and analysis.
PDF 1 MB
Article
Customer Spotlight: Northeast Laboratory Services
Article
Brochure
Comprehensive Testing Solutions for Feed Millers

Feed milling today is a complex business, and agribusinesses both large and small need to balance the nutritional and safety needs of livestock with availability of raw ingredients and their seasonality and variability. Add to that the valuable supplementation and medication that millers supply, and it’s clear: you’re creating a complete nutritional delivery system, not just a simple mix of grains.


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Grain Testing Solutions Brochure

The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.

PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.


PDF 6 MB
Meat and Seafood Testing Solutions

Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle.

Our commitment to you: to provide a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of food processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.

From instrumentation and software to consumables and reagents to service and support, we are dedicated to providing you with end-to-end solutions that ease your everyday challenges of automation, throughput, service, and time to results.


PDF 6 MB
NexION 1000 ICP Mass Spectrometer BrochurePerkinElmer's NexION 1000 ICP-MS is the ideal high-throughput system for running routine, multielemental, trace-level analyses that meet regulatory standards – and that works within your budget.
PDF 1001 KB
USP <232>/<233> & ICH Q3D Capabilities Brochure

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. In combination with the U.S. Pharmacopeia’s (USP) Chapters <232> and <233> on elemental impurities, they redefined how the pharmaceutical and related supply-chain industries will measure, document, and comply with strict new standards to limit the presence of elemental impurities in drug products.

PerkinElmer provides the tools and processes you need to take control of impurities testing for both drug substances and drug products, providing proven, reliable technology for the identification and quantification of elemental impurities and the accurate measurement of residual solvents in accordance with strict regulatory guidelines.

Download this brochure to learn more.


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Catalog
Atomic Spectroscopy 2018-2019 Consumables & Supplies CatalogWith instruments that are the industry standard worldwide, PerkinElmer accessories, consumables, methods and application support meet the most demanding requirements and are the preferred choice in thousands of laboratories globally.
PDF 8 MB
Ebook
Palm Oil Analysis. Complete lab solutions from upstream to downstream

Quality control-monitoring and testing are important in ensuring the quality of palm oil. The quality control parameters are used to judge the quality of palm oil products and it can be monitored and tested to ensure that the palm oil is not deliberately or accidentally adulterated.


PDF 11 MB
Flyer
S20 Series Autosamplers

The S20 series is the next generation of high-performance, robust, and agile autosamplers designed specifically for PerkinElmer’s spectroscopy platforms - atomic and molecular. The series is comprised of two autosamplers: the S23 with three racks and the S25 with five racks. They are designed to meet the needs of all types of laboratories requiring:

Capacity - up to 270 samples for the S23 and up to 450 samples for the S25 allowing long, unattended runs
Speed - intelligent acceleration and deceleration speed in three axes
Ease of use - full control through various software platforms: Syngistix™ (for AA, ICP-OES and ICP-MS), UVWinLab and SpectrumFL

PDF 1 MB
Guide
Atomic Spectroscopy, A Guide to Selecting the Appropriate Technique and System

Atomic spectroscopy is a family of techniques for determining the elemental composition of an analyte by its electromagnetic or mass spectrum. Several analytical techniques are available:

Atomic absorption (AA): flame and graphite furnace
Inductively coupled plasma optical emission spectroscopy (ICP-OES)
Inductively coupled plasma mass spectrometry (ICP-MS)
And selecting the most appropriate one is the key to achieving accurate, reliable, real-world results.

This guide provides a basic overview of the most commonly used techniques and the information necessary to help you select the one that best suits your specific needs and applications.


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NexION 1000/2000 ICP-MS Preparing Your LaboratoryPerkinElmer ICP-MS instruments are complete systems with the exception of the following items which must be provided by the customer: electrical power, exhaust vents, argon gas supplies with approved regulator, cell gas supply with approved regulators
PDF 1 MB
NexION 1000/2000/5000 ICP-MS Consumables & Supplies GuideLook to PerkinElmer for all of your consumables and supplies for your NexION 1000, 2000, or 5000 ICP-MS system.
PDF 3 MB
Infographic
Polymer Buyers Guide to Materials Lifecycle Testing
Infographic
Poster
EPA Compliant and Interference Free Monitoring of Agricultural Waste by ICPMSThe activities of working farms and ranches can have a significant environmental impact through the introduction of heavy metals. The advantages of ICP-MS for trace metal determination in waste streams are its sensitivity towards detecting low concentrations, wide linear dynamic range and rugged sample introduction. Innovative advances in ICP-MS technology have allowed for expanded capabilities including the analysis of more difficult, complex matrices and interferences which in the past have hindered ultra low-level detection of certain elements.
PDF 725 KB
The Accurate Quantification of Low-PPT Hexavalent Chromium in Water
PDF 585 KB
Product Note
High Throughput System for ICP-MS and ICP-OES Product Note

Our High Throughput System (HTS) is a uniquely designed modular sample introduction that integrates with the NexION® series of ICP-MS and the Avio® series of ICP-OES to dramatically reduce sample-to-sample time, thereby improving sample throughput while maintaining operation simplicity. The HTS maximizes productivity by significantly reducing the time required for the sample uptake, stabilization, and washout.

This valve-driven system is fully integrated with the Syngistix platform, eliminating the need for third-party software. Using a metal-free fluid path, the system quickly delivers the sample to the plasma, providing excellent results. With simple programming and workflow, the NexION ICP-MS and Avio ICP-OES with HTS simplifies method development for high-throughput analyses, allowing you to dramatically increase the number of samples you can analyze per day.


PDF 1 MB
Syngistix Atomic Spectroscopy Enhanced Security Software Product NotePerkinElmer’s Syngistix Enhanced Security software for AA, ICP and ICP-MS meets the special needs of highly regulated labs such as those that must comply with the U.S. FDA’s 21 CFR Part 11 regulations.
PDF 1 MB
Syngistix Cross-Platform Atomic Spectroscopy Software

PerkinElmer's Syngistix™ is a workflow-based software designed to offer a harmonized user experience across PerkinElmer’s AA, ICP and ICP-MS platforms.


PDF 757 KB
Syngistix Nano Application Software Module for Single Particle ICP-MS
PDF 758 KB
Regulatory Compliance Certification
Nexion 1000 and 2000 REACH Declaration
PDF 24 KB
Product Certificate - NexION 1000/2000Product Certificate for the NexION 1000/2000
PDF 98 KB
Technical Note
Advantages of a Novel Plasma Generator for the NexION 1000/2000/5000 ICP-MS Systems

Unlike other ICP-MS systems on the market that utilize conventional 40-MHz or 27-MHz commercially available generators which are typically customized and modified to work with ICP-MS instruments, the NexION® 1000/2000/5000 ICP-MS systems feature a 34-MHz frequency free-running RF generator, which was developed specifically for applications using ICP-MS systems. This state-of-the-art RF generator offers a trouble-free user experience, featuring adjustable power with 1 watt increments from 400 to 1600 watts. The accurate impedance matching of this system allows the plasma to quickly adjust to changing sample matrices, ensuring that sensitivity is maintained.

Learn more about the novel 34-MHz RF generator of the NexION 1000/2000/5000 ICP-MS - download this technical note.


PDF 986 KB
All Matrix Solution System for NexION ICP-MS Platforms

PerkinElmer’s AMS system provides a number of benefits to simplify analysis of high-matrix samples with theNexION family of ICP-MS instruments. By introducing a flow of argon into the spray chamber neck, the aerosol stream is diluted,allowing for more efficient ionization, fewer matrix effects, and less deposition on the interface cones, which results in simplifiedsample preparation and higher quality data.